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Antabuse produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Antabuse blocks the oxidation of alcohol at the acetaldehyde stage. During alcohol metabolism after antabuse intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to as the antabuse-alcohol reaction. This reaction, which is proportional to the dosage of both antabuse and alcohol, will persist as long as alcohol is being metabolized. Antabuse does not appear to influence the rate of alcohol elimination from the body.
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